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伊曲康唑三唑酮侧链的合成工艺改进

Ai-qiong Jia,Hong-bin Zhou,Lin Chen,Ling Wang

Chinese Journal of Antibiotics（2012）

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Abstract
探索化合物4-[4-[4-(羟基苯基)-1-哌嗪基]苯基]-2,4-二氢-2-(1-甲基丙基)-3H-1,2,4-三唑-酮(A)的简便易行的合成方法.在不影响反应收率的前提下,找到了新的试剂代替文献中所用的价格昂贵或者毒性较大的试剂,既节约试剂成本又简化操作程序,制得化合物A.
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Key words
4-[4-[4-(hydroxybenzyl)-piperazinyl]benzyl]-2,4-dihydro-2-(1-methyl propyl)-3H-1,2-,4-triazone,Reagent,Substitute,Synthesis
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