Correlation between Stro-1+ cells and bone morphogenetic protein and its receptor in proximal femur

Background: A successful osseointegration after total hip arthroplasty relies on the bone reconstruction around the prosthesis. Bone marrow mesenchymal stem cells are recruited and the commitment of bone marrow mesenchymal stem cells to an osteoblastic differentiation pathway is apparently under the control of bone morphogenic proteins. Objective: To analyze the correlation between Stro-1+ bone marrow mesenchymal stem cells and bone morphogenetic protein 7 and bone morphogenetic protein receptor in proximal femur. Methods: Bone samples were obtained from the discarded metaphysis region of the proximal femur in 32 patients with primary total hip arthroplasty, and the number of bone marrow mesenchymal stem cells was measured after in vitro cultured for 14 days. Stro-1+ was used to mark the stem cells. The expression of bone morphogenetic protein 7, bone morphogenetic protein receptor 1a and bone morphogenetic protein receptor 2 was detected. Results and Conclusion: There were differences of Stro-1+ cells, bone morphogenetic protein 7, bone morphogenetic protein receptor 1a and bone morphogenetic protein receptor 2 expression between different years, but the differences were not significant, and there was no significant difference between genders. There was a negative correlation between the numbers of Stro-1+ cells in proximal femur and expression of bone morphogenetic protein 7 that means the cell had the function to differentiate into osteoblasts. The correlation between the number of Stro-1+ cells and expression of bone morphogenetic protein receptor 1a was positive which can influence the fusion rate and the survival rate of the hip prosthesis.