Assessment of 18F-Labeled Mitochondrial Complex I Inhibitors As PET Myocardial Perfusion Imaging Agents in Rats, Rabbits, and Primates.

Ming Yu,Mary Guaraldi,Mikhail Kagan,Mahesh Mistry,Jennifer McDonald,Jody Bozek,Padmaja Yalamanchili,Megan Hayes,Michael Azure,Ajay Purohit,Heike Radeke,David S. Casebier,Simon P. Robinson

European journal of nuclear medicine and molecular imaging（2008）

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摘要

Myocardial extractions of mitochondria complex I (MC-I) inhibitors were high and well correlated with flow. This study assessed the potential of MC-I inhibitors to be developed as myocardial perfusion imaging (MPI) agents.

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关键词

Mitochondrial complex I Inhibitor,18F,Cardiac PET,Myocardial perfusion imaging

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