Amidine Derived Inhibitors Of Acid Sensing Ion Channel 3 (Asic3)

Scott D. Kuduk,Ronald K. Chang,Christina Ng Di Marco,Jenny Wai, Victoria Cofre,Robert M. Dipardo,Sean P. Cook,Matthew J. Cato,Aneta Jovanovska,Mark O. Urban,Michael Leitl,Stefanie A. Kane,Mark T. Bilodeau

Bioorganic & Medicinal Chemistry Letters（2009）

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摘要

A series of indole amidines modified at the 2-position of the indole ring were evaluated as inhibitors of Acid-Sensing Ion Channel-3 (ASIC3), a novel target for the treatment of chronic pain.

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关键词

Amiloride,Pain,ASIC3,Acidosis

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