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Potent and Orally Bioavailable Zwitterion GnRH Antagonists with Low CYP3A4 Inhibitory Activity

Chen,Yongsheng Chen,Joseph Pontillo,Zhiqiang Guo,Charles Q. Huang,Dongpei Wu,Ajay Madan,Takung Chen,Jenny Wen,Qiu Xie,Fabio C. Tucci,Martin Rowbottom,Yun-Fei Zhu,Warren Wade,John Saunders,Haig Bozigian,R. Scott Struthers

Bioorganic & medicinal chemistry letters（2008）

引用 16|浏览43
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关键词
zwitterion,gonadotropin-releasing hormone,receptor,antagonist,CYP3A4,inhibition,structure-activity relationship
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