Kilogram-Scale Synthesis of the CXCR4 Antagonist GSK812397

Sharon Boggs,Vassil I. Elitzin,Kristjan Gudmundsson,Michael T. Martin,Matthew J. Sharp

ORGANIC PROCESS RESEARCH & DEVELOPMENT（2009）

引用 76|浏览20

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摘要

An improved, scalable synthesis of the CXCR4 antagonist GSK812397 is described. This new route was recently scaled up in 50 L fixed equipment to afford 1.2 kg of drug substance in five steps with an overall yield of 20% and >99% chemical and enantiomeric purity.

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关键词

cxcr4,synthesis,kilogram-scale

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