Antagonists Of The Human A(2a) Receptor. Part 5: Highly Bio-Available Pyrimidine-4-Carboxamides
Bioorganic & Medicinal Chemistry Letters(2009)
摘要
A novel series of antagonists of the human A(2A) receptor have been identified and have been shown to display good potency and high degrees of selectivity over other receptor sub-types. Displaying in vivo potency in commonly used disease models and high oral bio-availability, this class of compounds may serve as clinically useful treatments for the relief of the symptoms associated with Parkinson's disease. (C) 2009 Elsevier Ltd. All rights reserved.
更多查看译文
关键词
Adenosine receptor, Parkinson's disease, Pyrimidine, Carboxamide
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要