Glucose-regulated Protein is Induced by Ionizing Radiation in Cancer

Glucose-regulated protein (GRP78) is a major endoplasmic reticulum chaperone with calcium-binding properties that suppresses stress-induced apoptosis. High GRP78 levels have been shown to correlate with a worse pathologic Grade, recurrence, and poor patient survival in breast, colon, liver, prostate carcinomas, and gliomas. The GRP78 is present in high levels in a vast number of tumors, and has been shown to confer chemoresistance to tumors and tumor-associated endothelial cells. The goal of this study is to elucidate the biochemical pathway(s) responsible for radiation-mediated neoantigen expression in tumor microvasculature.