Biaryl Substituted Hydantoin Compounds As Tace Inhibitors

Bioorganic & medicinal chemistry letters（2017）

引用 24|浏览41

暂无评分

摘要

We have identified a series of hydantoin-derived TNF-a converting enzyme (TACE) inhibitors containing a pendant fused bi-heteroaryl group, which demonstrate sub-nanomolar potency (Ki), excellent activity in human whole blood assay, and improved DMPK profiles over prior series.

查看译文

关键词

Tumor necrosis factor-alpha,TACE inhibitors,Hydantoin

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要