Population Pharmacokinetic Analysis of Letrozole in Japanese Postmenopausal Women
European journal of clinical pharmacology(2011)
摘要
Letrozole is an orally active aromatase inhibitor for the treatment of breast cancer. The objectives of this study were to examine the pharmacokinetic profile of letrozole in Japanese subjects and to identify factors that influence variability in the pharmacokinetics of letrozole using population pharmacokinetic (PPK) analysis.
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关键词
CYP2A6,Letrozole,NONMEM,Pharmacogenomics,Population pharmacokinetic analysis
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