Serum selenium in acute infections

We measured the serum selenium concentration in 64 patients with uncomplicated viral (n=33) or bacterial (n=31) infections during the acute stage of infection, during the early convalescent phase and after a minimum recovery period of three weeks and compared it to serum iron values. Both selenium (mean ± SEM: 70.3±2.3 µg/l vs 79.4±2.2 µg/l, p<0.0001) and iron (8.4±0.8 µg/l vs 16.7±0.9 µg/l, p<0.0001) concentrations showed significant depressions in the acute stage of infection compared with the values after the recovery. The reduction of serum selenium did not correlate with the severity of infection measured by fever. We conclude that acute infections decrease serum selenium levels regardless of the infective agent. The changes are of interest because of the possible connection between selenium and the immune system.