Dual pro-drugs of 2'-C-methyl guanosine monophosphate as potent and selective inhibitors of hepatitis C virus.
Bioorganic & Medicinal Chemistry Letters(2011)
Abstract
Various 6-substituted 2′-C-methylguanosines are prepared and converted to their 5′-ProTides. In almost every case the parent nucleosides are poorly active versus HCV while the ProTides are ca 100 fold more active.
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Key words
HCV,ProTide,Phosphoramidate,Nucleoside,Nucleotide,Polymerase,NS5B
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