182: Pharmacokinetics of Bupropion in Pregnant Women

ObjectiveThe objective of the study was to evaluate the pharmacokinetics (PK) of bupropion in pregnant women at different gestational ages including middle pregnancy (22-26 weeks), late pregnancy (34-38 weeks), and 12-16 weeks postpartum.Study DesignBupropion was prescribed to pregnant women with depression (n=9), smokers (n=2), or smokers with depression (n=3). These patients received an oral dose of bupropion (75, 100, or 150 mg) twice per day. After reaching steady state, bupropion pharmacokinetic data were then studied following a single dose. Blood samples were taken at time zero and 0.5, 1, 1.5, 2, 3, 4, 6, 8, 10, and 12 hours post-dosing. The concentration of bupropion in patients' plasma was determined by HPLC-UV. PK parameters were estimated utilizing standard noncompartmental techniques.ResultsSteady state PK parameters of bupropion (mean ± standard deviation) are presented in the following table.Tabled 1Gestational period:Middle Pregancy (22-26 weeks), n=7Late Pregnancy (34-38 weeks), n=6Postpartum (12-16 weeks), n=3AUC 0-12h, normalizedaAUC and Cmax were normalized by dividing the values by the mg/kg dose received. (ng·h/mL per mg/kg)504 ± 187480 ± 216535 ± 204Cmax, normalized (ng/mL per mg/kg)123 ± 69106 ± 52137 ± 47Tmax (h)1.7 ± 0.71.4 ± 0.41.3 ± 0.6CL/F (L/h)175 ± 72226 ± 163147 ± 57CL/F (L/h/kg)2.2 ±0.72.5 ± 1.42.0 ± 0.7a AUC and Cmax were normalized by dividing the values by the mg/kg dose received. Open table in a new tab ConclusionsThe AUC and Cmax values during pregnancy appear to be similar to the postpartum (non-pregnant) values. Since the small sample size currently precludes comparison between groups, further investigation is underway. ObjectiveThe objective of the study was to evaluate the pharmacokinetics (PK) of bupropion in pregnant women at different gestational ages including middle pregnancy (22-26 weeks), late pregnancy (34-38 weeks), and 12-16 weeks postpartum. The objective of the study was to evaluate the pharmacokinetics (PK) of bupropion in pregnant women at different gestational ages including middle pregnancy (22-26 weeks), late pregnancy (34-38 weeks), and 12-16 weeks postpartum. Study DesignBupropion was prescribed to pregnant women with depression (n=9), smokers (n=2), or smokers with depression (n=3). These patients received an oral dose of bupropion (75, 100, or 150 mg) twice per day. After reaching steady state, bupropion pharmacokinetic data were then studied following a single dose. Blood samples were taken at time zero and 0.5, 1, 1.5, 2, 3, 4, 6, 8, 10, and 12 hours post-dosing. The concentration of bupropion in patients' plasma was determined by HPLC-UV. PK parameters were estimated utilizing standard noncompartmental techniques. Bupropion was prescribed to pregnant women with depression (n=9), smokers (n=2), or smokers with depression (n=3). These patients received an oral dose of bupropion (75, 100, or 150 mg) twice per day. After reaching steady state, bupropion pharmacokinetic data were then studied following a single dose. Blood samples were taken at time zero and 0.5, 1, 1.5, 2, 3, 4, 6, 8, 10, and 12 hours post-dosing. The concentration of bupropion in patients' plasma was determined by HPLC-UV. PK parameters were estimated utilizing standard noncompartmental techniques. ResultsSteady state PK parameters of bupropion (mean ± standard deviation) are presented in the following table.Tabled 1Gestational period:Middle Pregancy (22-26 weeks), n=7Late Pregnancy (34-38 weeks), n=6Postpartum (12-16 weeks), n=3AUC 0-12h, normalizedaAUC and Cmax were normalized by dividing the values by the mg/kg dose received. (ng·h/mL per mg/kg)504 ± 187480 ± 216535 ± 204Cmax, normalized (ng/mL per mg/kg)123 ± 69106 ± 52137 ± 47Tmax (h)1.7 ± 0.71.4 ± 0.41.3 ± 0.6CL/F (L/h)175 ± 72226 ± 163147 ± 57CL/F (L/h/kg)2.2 ±0.72.5 ± 1.42.0 ± 0.7a AUC and Cmax were normalized by dividing the values by the mg/kg dose received. Open table in a new tab Steady state PK parameters of bupropion (mean ± standard deviation) are presented in the following table. ConclusionsThe AUC and Cmax values during pregnancy appear to be similar to the postpartum (non-pregnant) values. Since the small sample size currently precludes comparison between groups, further investigation is underway. The AUC and Cmax values during pregnancy appear to be similar to the postpartum (non-pregnant) values. Since the small sample size currently precludes comparison between groups, further investigation is underway.