Early Mechanical Restraint Improves Border Zone Function During Infarction Induced Ventricular Remodeling

J.J Pilla,A.S Blom,J Affuso,V.A Ferrari, J.H Gorman,R.C Gorman,M.A Acker

The journal of heart and lung transplantation/The Journal of heart and lung transplantation（2004）

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摘要

Background: Early infarct expansion leads to contractile dysfunction of normally perfused borderzone myocardium (BZ). Over time BZ contractile dysfunction becomes more severe and the phenomenon extends centripetally out from the infarct to involve progressively more normally perfused myocardium. Using a well described ovine model we tested the hypothesis that early ventricular restraint preserves BZ contractile function during infarction induced remodeling.

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