OC99: Should We Recommend Invasive Study in Fetuses with Isolated Borderline Ventriculomegaly?

To assess the clinical availability of invasive study (fetal karyotyping and TORCH study) in fetuses with isolated borderline ventriculomegaly. A computerized ultrasonography database identified fetuses with isolated borderline ventriculomegaly (atrial width of lateral ventricles 10–12 mm and no other sonographic abnormality) at 19–37 weeks of gestation from September 2004 to August 2006 in Cheil General Hospital. Only cases with a known pregnancy outcome were included in this study. We reviewed the medical records of these pregnant women and infants for the incidence of chromosomal abnormalities and viral infection. During study period, 21 944 fetuses underwent routine ultrasonographic examination in our institute. Among them, 131 fetuses were diagnosed with isolated borderline ventriculomegaly and neonatal outcome was known. The mean maternal age was 31.5 ± 3.9 (range, 23.0–46.0) years. The median gestational age at first diagnosis with isolated borderline ventriculomegaly was 28.0 (range, 19.2–37.5) weeks. Among this group, invasive study was undertaken in 47 cases (35.8%). Twelve fetuses underwent both fetal karyotyping and TORCH study. There was no case with an abnormal karyotyping result or positive result in the TORCH study. In cases of isolated borderline ventriculomegaly, routine invasive study for fetal karyotyping and TORCH cannot be justified.