Genomewide Clonal. Analysis of Lethal Mutations in the Drosophila Melanogaster Eye: Comparison of the X Chromosome and Autosomes Gerald B. Call , John M. Olson , Jiong Chen , Nikki Villarasa , Kathy T. Ngo , Allison M. Yabroff , Shawn Cokus , Matteo Pellegrini , Elena Bibikova , Chris Bui , Albert Cespedes , Cheryl Chan , Stacy Chan , Amrita K. Cheema , Akanksha Chhabra , Vida Chitsazzadeh , Minh-Tu Do , Q. Angela Fang , Andrew Folick , Gelsey L. Goodstein , Cheng R. Huang , Tony Hung , Eunha Kim , William Kim , Yulee Kim , Emil Kohan , Edward Kuoy , Robert Kwak , Eric Lee , JiEun Lee , Henry Lin , H-C. Angela Liu , Tatiana Moroz , Tharani Prasad , Sacha L. Prashad , Alexander N. Patananan , Alma Rangel , Desiree Rosselli , Sohrab Sidhu , Daniel Sitz , Chelsea E. Taber , Jingwen Tan , Kasey Topp , PhuongThao Tran , Quynh-Minh Tran , Mary Unkovic , Maggie Wells , Jessica Wickland , Kevin Yackle , Amir Yavari , Jesse M. Zaretsky , Christopher M. Allen , Latifat Alli , Ju An , Abbas Anwar , Sonia Arevalo , Danny Ayoub , Shawn S. Badal , Armonde Baghdanian , Arthur H. Baghdanian , Sara A. Baumann , Vivian N. Becerra , Hei J. Chan , Aileen E. Chang , Xibin A. Cheng , Mabel Chin , Fleurette Chong , Carlyn Crisostomo , Sanjit Datta , Angela Delosreyes , Francie Diep , Preethika Ekanayake , Mark Engeln , Elizabeth Evers , Farzin Farshidi , Katrina Fischer , Arlene J. Formanes , Jun Gong , Riju Gupta , Blake E. Haas , Vicky Hahm , Michael Hsieh , James Z. Hui , Mei L. Iao , Sophia D. Jin , Angela Y. Kim , Lydia S-H. Kim , Megan King , Chloe Knudsen-Robbins , David Kohanchi , Bogdana Kovshilovskaya , Amy Ku , Raymond W. Kung , Mark E. L. Landig , Stephanie S. Latterman , Stephanie S. Lauw , Daniel S. Lee , Joann S. Lee , Kai C. Lei , Lesley L. Leung , Renata Lerner , Jian-ya Lin , Kathleen Lin , Bryon C. Lim , Crystal P. Y. Lui , Tiffany Q. Liu , Vincent Luong , Jacob Makshanoff , An-Chi Mei , Miguel Meza , Yara. A. Mikhaeil , Majid Moarefi , Long H. Nguyen , Shekhar S. Pai , Manish Pandya , Aadit R. Patel , Paul D. Picard , Michael M. Safaee , Carol Salame , Christian Sanchez , Nina Sanchez , Christina C. Seifert , Abhishek Shah , Oganes H. Shilgevorkyan , Inderroop Singh , Vanessa Soma , Junia J. Song , Neetika Srivastava , Jennifer L. Sta. Ana , Christie Sun , Diane Tan , Alison S. Teruya , Robyn Tikia , Trinh Tran , Emily G. Travis , Jennifer D. Trinh , Diane Vo , Thomas Walsh , Regan S. Wong , Katherine Wu , Ya-Whey Wu , Nkau X. V. Yang , Michael Yeranosian , James S. Yu , Jennifer J. Zhou , Ran X. Zhu , Anna Abrams , Amanda Abramson , Latiffe Amado , Jenny Anderson , Keenan Bashour , Elsa Beyer , Allen Bookatz , Sarah Brewer , Natalie Buu , Stephanie Calvillo , Joseph Cao , Amy Chan , Jenny Chan , Aileen Chang , Daniel Chang , Yuli Chang , YiBing Chen , Joo Choi , Jeyling Chou , Peter Dang , Sumit Datta , Ardy Davarifar , Artemis Deravanesian , Poonam Desai , Jordan Fabrikant , Shahbaz Farnad , Katherine Fu , Eddie Garcia , Nick Garrone , Srpouhi Gasparyan , Phyllis Gayda , Sherrylene Go , Chad Goffstein , Courtney Gonzalez , Mariam Guirguis , Ryan Hassid , Brenda Hermogeno , Julie Hong , Aria Hong , Lindsay Hovestreydt , Charles Hu , Devon Huff , Farid Jamshidian , James Jen , Katrin Kahen , Linda Kao , Melissa Kelley , Thornas Kho , Yein Kim , Sarah Kim , Brian Kirkpatrick , Adam Langenbacher , Santino Laxamana , Janet Lee , Chris Lee , So-Youn Lee , ToHang S. Lee , Toni Lee , Gemma Lewis , Sheila Lezcano , Peter Lin , Thanh Luu , Julie Luu , Will Marrs , Erin Marsh , Jamie Marshall , Sarah Min , Tanya Minasian , Helena Minye , Amit Misra , Miles Morimoto , Yasaman Moshfegh , Jessica Murray , Kha Nguyen , Cynthia Nguyen , Ernesto Nodado , Amanda O'Donahue , Ndidi Onugha , Nneka Orjiakor , Bhavin Padhiar , Eric Paul , Mara Pavel-Dinu , Alex Pavlenko , Edwin Paz , Sarah Phaklides , Lephong Pham , Preethi Poulose , Russell Powell , Aya Pusic , Divi Ramola , Kirsten Regalia , Meghann Ribbens , Bassel Rifai , Manyak Saakyan , Pamela Saarikoski , Miriam Segura , Farnaz Shadpour , Aram Shemmassian , Ramnik Singh , Vivek Singh , Emily Skinner , Daniel Solomin , Kosha Soneji , Kristin Spivey , Erika Stageberg , Marina Stavchanskiy , Leena Tekchandani , Leo Thai , Jayantha Thiyanaratnam , Maurine Tong , Aneet Toor , Steve Tovar , Kelly Trangsrud , Wah-Yung Tsang , Marc Uemura , Emily Vollmer , Emily Weiss , Damien Wood , Joy Wu , Sophia Wu , Winston Wu , Qing Xu , Yuki Yamauchi , Will Yarosh , Laura Yee , George Yen , Utpal Banerjee Genetics（2007）
摘要
Using a large consortium of undergraduate students in an organized program at the University of California, Los Angeles (UCLA), we have undertaken a functional genomic screen in the Drosophila eye. In addition to the educational value of discovery-based learning, this article presents the first comprehensive genomewide analysis of essential genes involved in eye development. The data reveal the surprising result that the X chromosome has almost twice the frequency of essential genes involved in eye development as that found on the autosomes.
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