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Trifluoromethylphenyl as P2 for ketoamide-based cathepsin S inhibitors.

Jiaqiang Cai,John Robinson,Simone Belshaw,Kathryn Everett,Xavier Fradera,Mario van Zeeland,Leon van Berkom,Peter van Rijnsbergen,Lucy Popplestone,Mark Baugh,Maureen Dempster,John Bruin,William Hamilton,Emma Kinghorn,Paul Westwood,Jennifer Kerr,Zoran Rankovic,Wullie Arbuckle,D Jonathan Bennett,Philip S Jones,Clive Long,Iain Martin,Joost C M Uitdehaag,Tommi Meulemans

Bioorganic & Medicinal Chemistry Letters（2010）

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关键词
Cathepsin s,Cathepsin k,Ketoamide,Aldehyde,X-ray structure
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