Loss of the actin remodeler Eps8 causes intestinal defects and improved metabolic status in mice.
PLOS ONE(2010)
摘要
BACKGROUND:In a variety of organisms, including mammals, caloric restriction improves metabolic status and lowers the incidence of chronic-degenerative diseases, ultimately leading to increased lifespan.
METHODOLOGY/PRINCIPAL FINDINGS:Here we show that knockout mice for Eps8, a regulator of actin dynamics, display reduced body weight, partial resistance to age- or diet-induced obesity, and overall improved metabolic status. Alteration in the liver gene expression profile, in behavior and metabolism point to a calorie restriction-like phenotype in Eps8 knockout mice. Additionally, and consistent with a calorie restricted metabolism, Eps8 knockout mice show increased lifespan. The metabolic alterations in Eps8 knockout mice correlated with a significant reduction in intestinal fat absorption presumably caused by a 25% reduction in intestinal microvilli length.
CONCLUSIONS/SIGNIFICANCE:Our findings implicate actin dynamics as a novel variable in the determination of longevity. Additionally, our observations suggest that subtle differences in energy balance can, over time, significantly affect bodyweight and metabolic status in mice.
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关键词
energy balance,physics,obesity,chemistry,body weight,biology,engineering,metabolism,medicine,actin,knockout mice
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