Discovery of Small Molecule Human FPR1 Receptor Antagonists

John Unitt,Malbinder Fagura,Tim Phillips,Sarah King,Matthew Perry,Andrew Morley,Cathy MacDonald,Richard Weaver,Jadeen Christie,Simon Barber,Rukhsana Mohammed,Melanie Paul,Andrew Cook,Andrew Baxter

Bioorganic & medicinal chemistry letters（2011）

引用 27|浏览20

暂无评分

摘要

The identification of two novel series of formyl peptide receptor 1 (FPR1) antagonists are reported, represented by methionine benzimidazole 6 and diamide 7. Both series specifically inhibited the binding of labelled fMLF to hrFPR1 and selectively antagonized FPR1 function in human neutrophils, making them useful in vitro validation tools for the target.

查看译文

关键词

FPR1 antagonist,Hit-to-lead,Small molecule

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要