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Design, synthesis, and evaluation of novel aryl-tetrahydropyridine PPARα/γ dual agonists

Eunkyung Kim,Chan Sun Park,Taedong Han,Myung-Ho Bae,Wonee Chong,Choong Hyun Lee,Young Ah Shin,Byung-Nak Ahn,Mi Kyung Kim,Chang Yell Shin,Moon Ho Son,Jin Kwan Kim,Ho Sang Moon,Hyun Joo Shim,Eun Jung Kim,Soon Hoe Kim,Joong In Lim,Chun Ho Lee

Bioorganic & Medicinal Chemistry Letters（2008）

Cited 12|Views30
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Abstract
The synthesis of the potent PPARα/γ dual agonist (S)-5b (EC50=1.73/0.64μM (α/γ)) is reported.
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Key words
Type 2 diabetes,PPARs,PPARα/γ dual agonists,Tetrahydropyridine
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