UNALTERED STIMULATION OF PITUITARY ADRENOCORTICOTROPHIN SECRETION BY CORTICOTROPHIN‐RELEASING FACTOR FOLLOWING SODIUM VALPROATE ADMINISTRATION IN A PATIENT WITH NELSON'S SYNDROME

A 53-year-old woman with Nelson's syndrome was treated with 600 mg sodium valproate daily. Her plasma ACTH was effectively decreased, whilst the response of plasma ACTH to corticotrophin-releasing factor (CRF) was unaltered. The result of the CRF test suggested that sodium valproate, at least in the present patient, acted at the hypothalamic level.