Synthesis of Novel [1-Aziridinyl-(hydroxyimino) Methyl]Arenes and Their Cytotoxic Activity
Chemistry of heterocyclic compounds(2009)
摘要
The synthesis has been developed for novel potential anticancer agents whose structures contain an aziridine amidoxime group. The cytotoxic activity of all of the target compounds on different cell lines are given together with the in vitro IC50 and LD50 values found. The most promising anticancer agents were found to be the methyl 4-[1-aziridinyl(hydroxyimino)methyl] benzoate, 1-aziridinyl(2-naphthyl)methanone oxime, and 1-aziridinyl(2-quinolyl)methanone oxime.
更多查看译文
关键词
aziridine,amidoximes,hydroxyimidoyl chlorides,oximes,cytotoxic activity
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要