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Optimisation of pharmacokinetic properties to afford an orally bioavailable and selective V1A receptor antagonist.

William Arbuckle,James Baker,David Barn,Matilda Bingham,Angus Brown,Kirsteen Buchanan,Mark Craighead,Richard Goodwin,Susan Goutcher,Michael Kiczun,Amanda Lyons,Rachel Milne,Brian Montgomery,Susan Napier,Jeremy Presland,Hazel Sloan,Zara Turnbull,Grant Wishart

Bioorganic & Medicinal Chemistry Letters（2011）

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关键词
Peptide GPCR,Vasopressin antagonist,CNS penetration,P-glycoprotein
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