Identification of [4-[4-(methylsulfonyl)phenyl]-6-(trifluoromethyl)-2-pyrimidinyl] amines and ethers as potent and selective cyclooxygenase-2 inhibitors Martin E. Swarbrick , Paul J. Beswick , Robert J. Gleave , Richard H. Green , Sharon Bingham , Chas Bountra , Malcolm C. Carter , Laura J. Chambers , Iain P. Chessell , Nick M. Clayton , Sue D. Collins , John A. Corfield , C. David Hartley , Savvas Kleanthous , Paul F. Lambeth , Fiona S. Lucas , Neil Mathews , Alan Naylor , Lee W. Page , Jeremy J. Payne , Neil A. Pegg , Helen S. Price , John Skidmore , Alexander J. Stevens , Richard Stocker , Sharon C. Stratton , Alastair J. Stuart , Joanne O. Wiseman BIOORGANIC & MEDICINAL CHEMISTRY LETTERS（2009）
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Cyclooxygenase, COX-2, Pyrimidine, CNS penetrant
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