Selective Binding of the Dipeptides L-Phe-D-Pro and D-Phe-L-Pro to Beta-Cyclodextrin

M Maletic,H Wennemers,DQ McDonald,R Breslow,WC Still

Angewandte Chemie International edition in English（1996）

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摘要

A combinatorial approach revealed the highly selective binding of the dipeptides L-Phe-D-Pro and D-Phe-L-Pro to β-cyclodextrin. NMR spectroscopy and molecular modeling provide a picture of the possible binding mode and an explanation of why those specific dipeptides were selected from the tripeptide library.

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关键词

combinatorial chemistry,cyclodextrins,molecular recognition,peptides

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