Discovery of (Pyridin-4-yl)-2h-tetrazole As a Novel Scaffold to Identify Highly Selective Matrix Metalloproteinase-13 Inhibitors for the Treatment of Osteoarthritis Mark E. Schnute , Patrick M. O'Brien , Joe Nahra , Mark Morris , W. Howard Roark , Cathleen E. Hanau , Peter G. Ruminski , Jeffrey A. Scholten , Theresa R. Fletcher , Bruce C. Hamper , Jeffery N. Carroll , William C. Patt , Huey S. Shieh , Brandon Collins , Alexander G. Pavlovsky , Katherine E. Palmquist , Karl W. Aston , Jeffrey Hitchcock , Michael D. Rogers , Joseph McDonald , Adam R. Johnson , Grace E. Munie , Arthur J. Wittwer , Chiu-Fai Man , Steven L. Settle , Olga Nemirovskiy , Lillian E. Vickery , Arun Agawal , Richard D. Dyer , Teresa Sunyer Bioorganic & medicinal chemistry letters（2010）
Key words
MMP, Osteoarthritis, DMOAD
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