The rational design of an iminosugar inhibitor able to mimic substrate distortion occurring during retaining-cellulase hydrolysis
Tetrahedron Letters(2001)
摘要
This paper reports the rational design, synthesis and biochemical evaluation of a new type of cellulase inhibitor. This isofagomine isomer analogous to the β-l-idopyranose linked to a glucosidic unit by a methylenic bond is able to mimic the pseudo-axial orientation of the ‘aglycon’ observed in the X-ray structure of a non-hydrolyzable thiooligosaccharide/cellulase complex.
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关键词
iminosugar inhibitor,hydrolysis,substrate distortion,retaining-cellulase
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