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Novel biodegradable lipid nano complex for siRNA delivery significantly improving the chemosensitivity of human colon cancer stem cells to paclitaxel

Changxing Liu,Gang Zhao,Jian Liu,Nianchun Ma,Padmanabh Chivukula, Loren Perelman,Keisaku Okada,Zongyou Chen,David Gough,Lei Yu

Journal of Controlled Release（2009）

Cited 113|Views26
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Abstract
A novel siRNA lipid nano complex with an MDR1-targeting siRNA (siMDR1) was synthesized. This complex was optimized for high transfection efficacy. Finally, specific knockdown of the MDR1 gene in CD133+ cells was also evaluated.
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Key words
Nanoparticle,Gene delivery,siRNA delivery,Non-viral carrier and lipid nanoparticle
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