An efficient, asymmetric solid-phase synthesis of benzothiadiazine-substituted tetramic acids: Potent inhibitors of the hepatitis C virus RNA-dependent RNA polymerase
Bioorganic & Medicinal Chemistry Letters(2006)
摘要
Solid-phase synthesis and SAR are described for a series of benzothiadiazine-substituted tetramic acid inhibitors of the hepatitis C virus RNA-dependent RNA polymerase, NS5B.
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关键词
Hepatitis C,HCV polymerase inhibitors,Solid-phase synthesis
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