Exploration of the molecular origin of the azinomycin epoxide: timing of the biosynthesis revealed.
ORGANIC LETTERS(2008)
摘要
Streptomyces sahachiroi whole cell feeding experiments, utilizing putative precursors labeled with stable isotopes, established that the epoxide unit of the DNA cross-linked agents, azinomycin A and B, proceeds via a valine-dependent pathway and that hydroxylation and dehydration precedes formation of the terminal epoxide. Sodium 3-methyl-2-oxobutenoate, formed through a transimination reaction, was shown to be the penultimate precursor incorporated into the azinomycin epoxide.
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关键词
azinomycin epoxide,biosynthesis,molecular origin
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