The enhancer shift: a model to explain the developmental control of IgH gene expression in B-lineage cells.

The roles attributed to the Eμ enhancer and the downstream 3′ regions acting as locus control regions (LCRs) have allowed comparisons to be drawn between regulation of the IgH locus in early and late B-cell development and other systems governed by LCR activity. Here, the importance of the IgH 3′LCR and its putative functional role in the control of IgH gene expression is evaluated and compared with the 5′LCR regulatory region of the human β-globin locus.