The Effect of Different Etiologies of Hepatic Impairment on the Pharmacokinetics of Gefitinib

Jiri Horak,Jeff White,Adrian L. Harris,Mark Verrill,James Carmichael,Alison Holt,Mireille Cantarini,Merran Macpherson,Alan Swaisland,Helen Swaisland,Chris Twelves

Cancer chemotherapy and pharmacology（2011）

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摘要

We investigated whether the pharmacokinetics and tolerability of gefitinib were altered in patients with hepatic impairment due to cirrhosis or hepatic metastases in two open, parallel-group, multicenter studies.

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关键词

Cirrhosis,Gefitinib,Hepatic impairment,Liver metastases,Pharmacokinetics

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