Early Prediction Of Neurodevelopmental Outcome In Symptomatic Congenital Cytomegalovirus (Cmv) Infection.

Twenty-four children with virologically confirmed symptomatic congenital CMV infection were prospectively studied to assess the predictive value of central nervous system (CNS) signs, symptoms, and radiographic abnormalities on neurodevelopmental outcome. Outcome was assessed by serial age-appropriate IQ testing and by complete physical, neurologic, and developmental examinations (mean age at most recent followup 4.4 yrs., range 11 mos. - 9 yrs.). Early CNS abnormalities seen were: abnormal head CT scan 22 patients, congenital sensorineural hearing loss (SNHL) 11, microcephaly 9, chorioretinitis 6, seizures 1, and other neurologic abnormalities(hypo/hypertonia, jitteriness, tremors) 11. The sum of CNS abnormalities for each patient was designated as that patient's CNS score, with scores of 0-6 possible (CNS score range 0-5, mean 2.5). Mental retardation (MR) (IQ 90(p<0.05).