Importance of assay specificity for plasma protein binding determinations.
Journal of pharmacokinetics and biopharmaceutics(2015)
摘要
Plasma or serum protein binding determinations of extensively bound drugs are subject to serious error if the analytical methods employed do not discriminate between such drugs and their degradation products, metabolites, and impurities. Experimental evidence is presented to demonstrate the magnitude of this problem with respect to warfarin.
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关键词
protein binding,equilibrium dialysis,warfarim,ultrafiltration,plasma proteins
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