Fluvastatin and Lovastatin Inhibit Granulocyte Macrophage–colony Stimulating Factor‐stimulated Human Eosinophil Adhesion to Inter‐cellular Adhesion Molecule‐1 under Flow Conditions

Background Eosinophil accumulation in the lung is an important feature of airway inflammation in asthma. There is therefore much interest in developing novel therapies to prevent this process. Accumulating evidence suggests that statins have anti‐inflammatory properties, including inhibition of leucocyte accumulation. We therefore assessed the ability of five statins to inhibit human eosinophil adhesion to recombinant human inter‐cellular adhesion molecule (rhICAM)‐1 under physiologically relevant flow conditions.