Effects Of 2 Novel Selective Estrogen Receptor Modulators, Raloxifene, Tamoxifen, And Ethinyl Estradiol On The Uterus, Vagina, And Breast In Ovariectornized Cynomolgus Monkeys (Macaca Fascicularis)

Paul Sikoski,Thomas C. Register,Cynthia J. Lees,Scott Lundeen, James Hutchison, Kathryn H. Brown,Mark Cline

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY（2007）

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摘要

We orally dosed 24 adult ovariectomized Macaca fasciculatis for 12 weeks with raloxifene, ethinyl estradiol, tamoxifen, and 2 novel selective estrogen receptor modulators (SERMs), SERM-393 and SERM-379, to assess the effects of SERMs on the reproductive system.

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