W1100 Uncoupling of EGFR-Snail Axis in Resistant Tumors During Polyethylene Glycol-Mediated Colon Cancer Chemoprevention

curcumin and sulindac sulfone alone and in combination on the growth of CRC cells In Vitro and In Vivo using the ACF model.Methods: Cell growth inhibition was assayed In Vitro.Apoptosis and cell cycle were scored by Annexin V and PI assays.Protein expression (COX-1,2, Cyclin D1, beta-catenin) was examined by Western blotting.In Vivo, the aberrant crypt foci (ACF) model in rats was performed following injections of DMH (100mg/kg) twice a week for 2 weeks.Results: Table 1: The effect of curcumin and sulindac sulfone on colon cancer cells Table 2: ACF formation in rats Conclusion: Curcumin can synergistically potentiate the growth inhibitory effect of low doses of sulindac sulfone In Vitro and In Vivo.The effect of curcumin and sulindac sulfone on colon cancer cells (**P<0.005)ACF formation in rats (**P<0.