Drug-Plastic Interactions II: Sorption of p-Hydroxybenzoic Acid Esters by Capran Polyamide and In Vitro, Biologic Activity

Sorption of methyl- and propylparaben by capran polyamide was determined by means of an equilibrium sorption method. Data are presented to show that the antimicrobial activity of the parabens for Aspergillus niger, Aerobacter aerogenes, and Pseudomonas aeruginosa is diminished in the presence of capran polyamide. The in vitro biologic activity of the parabens in the presence of the nylon was shown to be related to the concentration of “free” or the drug in equilibrium with the plastic.