Replacement of the positively charged Walker A lysine residue with a hydrophobic leucine residue and conformational alterations caused by this mutation in MRP1 impair ATP binding and hydrolysis.
BIOCHEMICAL JOURNAL（2006）
关键词
ATP binding/hydrolysis,ATP-dependent transport,conformation,multidrug resistance,multidrug resistance protein 1 (MRP1),nucleotide-binding domain
AI 理解论文
溯源树
样例
生成溯源树，研究论文发展脉络
Chat Paper
正在生成论文摘要