DNA-protein complexes
Applied Biochemistry and Biotechnology(1994)
摘要
Sera of patients with different types of leukemia and acquired immune deficiency syndrome (AIDS) have been examined for the
presence of the anti-DNA antibodies. DNA-hydrolyzing activity of antibodies was detected in the sera of patients with chronic
lymphoid leukemia (CLL), pre-B-cell acute lymphoid leukemia (pre-B-All), acute myeloleukosis (AML), and AIDS in stages III
and IV of the disease. In immunofluorescence tests, the DNA-hydrolyzing antibodies reacted preferentially with proliferating
cell nuclei compared with resting cells. A 35-kDa factor was identified as the target for the DNA antibodies in the cell nuclei.
The DNA-hydrolyzing antibody fraction from the serum of an AIDS patient crossreacted with HIV I virus proteins gp160, gp120,
and p65.
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关键词
aids.,dna,leukemia,nuclear staining,crossreactions,index entries: catalytic antibodies,indexation,protein complex
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