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研究领域是海洋微生物学和古菌分子生物学。研究兴趣是使用生物技术回答地球科学的问题,专注于研究古菌特有的细胞膜脂GDGTs(甘油二烷基甘油四醚)的生物合成机制。古菌GDGTs形成单分子层细胞膜,理化稳定性显著强于细菌和真核生物的磷脂双分子层细胞膜,它更是重要的分子化石,记录了从古至今海洋表面温度的变化。代表性研究成果包括首次发现并命名GDGTs合成酶基因(Tes),揭秘了GDGTs生物合成途径的关键步骤;破译了GDGTs环化酶基因(Grs),为应用GDGTs分子化石指示历史海洋温度变化奠定了理论基础;此外,还发现部分古菌进化出膜脂极性头热醇(calditol)合成酶基因(Cds),极大提高古菌耐受极端酸热环境的能力。主要研究手段包括古菌基因编辑技术,基因功能分析,脂类质谱分析,生物信息学等。未来继续探索未知的古菌膜脂合成机制,揭示古菌细胞膜结构及其生理功能,拓展分子化石的地球科学应用,以及研究古菌适应极端环境的机制等。
Research Interests
Papers共 100 篇Author StatisticsCo-AuthorSimilar Experts
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Wenpeng Cao,Jinzhi Lan,Chujiao Hu, Jinping Kong, Limin Xiang, Zhixue Zhang, Yating Sun,Zhirui Zeng,Shan Lei
AGING-USno. 6 (2024): 5618-5633
Meina He, Yaoyun Liang, Xiaoran Nie,Tuo Zhang, Danqing Zhao, Jixian Zhang,Huan Lin,Zhirui Zeng, Xingyu Song, Yitong Wang, Shiling Ran, Shuyun Zhao, Tengxiang Chen, Chunlin Zhang, Zhanhui Feng
American Journal of Physiology-Cell Physiology (2024)
crossref(2024)
Agingno. 12 (2024): 10462-10476
Shan Lei, Zhixue Zhang,Zhirui Zeng,Wenpeng Cao,Yating Sun,Dahuan Li,Jigang Pan, Yingmin Wu,Tuo Zhang,Tengxiang Chen
crossref(2024)
Oncology Researchno. 0 (2024): 1-10
MOLECULESno. 7 (2024)
Yanan Li, Ting Yu,Xi Feng, Bo Zhao,Huahui Chen,Huan Yang, Xing Chen,Xiao-Hua Zhang,Hayden R. Anderson,Noah Z. Burns,Fuxing Zeng,Lizhi Tao,Zhirui Zeng
Nature communicationsno. 1 (2024)
Feng Pan,Runsang Pan, Rui Hu,Hao Zhang,Shan Lei,Lu Zhang,Changhua Zhou,Zhirui Zeng,Xiaobin Tian, Quan Xie
JOURNAL OF CELLULAR AND MOLECULAR MEDICINEno. 10 (2024)
Nanxi Li,Peng Ren,Jingya Wang, Xiaohui Zhu, Xuan Qiao,Zhirui Zeng,Tong Ye, Shanshan Wang,Zhiyun Meng,Hui Gan,Shuchen Liu,Yunbo Sun,Xiaoxia Zhu,Guifang Dou,Ruolan Gu
International journal of molecular sciencesno. 2 (2024)
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Author Statistics
#Papers: 99
#Citation: 1066
H-Index: 18
G-Index: 31
Sociability: 6
Diversity: 3
Activity: 109
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