Haiming Zhang

基本信息

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职业迁徙

个人简介

MY FOCUS Strategic planning, route scouting and process development of various small molecule development candidates ranging from LSR to Ph3.

研究兴趣

论文共 128 篇作者统计合作学者相似作者

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Development of a First-Generation Stereocontrolled Manufacturing Process of TRPA1 Inhibitor GDC-6599

Allen Y. Hong,Katarzyna A. Piechowicz,Jacob C. Timmerman,Haiming Zhang,Carmela Molinaro,Francis Gosselin

ORGANIC PROCESS RESEARCH & DEVELOPMENTno. 6 (2024): 2325-2333

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Development of a Streamlined Manufacturing Process for the Highly Substituted Quinazoline Core Present in KRAS G12C Inhibitor Divarasib

Johannes A. Burkhard, Sebastian Herold, Christian Leitner,Haiming Zhang,Remy Angelaud,Qingping Tian,Chong Han, Francis Gosselin

ORGANIC PROCESS RESEARCH & DEVELOPMENTno. 1 (2024): 102-111

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Enantioselective Sulfonimidamide Acylation Via a Cinchona Alkaloid-Catalyzed Desymmetrization: Scope, Data Science, and Mechanistic Investigation

Brittany C. Haas,Ngiap-Kie Lim,Janis Jermaks,Eden Gaster,Melody C. Guo,Thomas C. Malig,Jacob Werth,Haiming Zhang,F. Dean Toste,Francis Gosselin,Scott J. Miller,Matthew S. Sigman

JOURNAL OF THE AMERICAN CHEMICAL SOCIETYno. 12 (2024): 8536-8546

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C1 Functionalization of Β-Carboline Via Knochel-Hauser Base-Directed Metalation and Negishi Coupling

Jin Tan, Kyle Clagg,Haiming Zhang

The Journal of organic chemistry (2024)

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Fit‐for‐Purpose Synthesis of CDK2 Inhibitor GNE‐140

Andrea Ambrosi,Katarzyna A. A. Piechowicz, Tyler A. A. Tuck,Di Xu,Haiming Zhang,Francis Gosselin

HELVETICA CHIMICA ACTAno. 8 (2023)

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Second-Generation Atroposelective Synthesis of KRAS G12C Covalent Inhibitor GDC-6036

Jie Xu,Ngiap-Kie Lim,Jacob C. Timmerman,Jeff Shen,Kyle Clagg,Ugo Orcel,Raphael Bigler, Etienne Trachsel,Roland Meier,Nicholas A. White,Johannes A. Burkhard,Lauren E. Sirois,Qingping Tian,Remy Angelaud,Stephan Bachmann,Haiming Zhang,Francis Gosselin

Organic lettersno. 19 (2023): 3417-3422

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Data Science-Enabled Palladium-Catalyzed Enantioselective Aryl-Carbonylation of Sulfonimidamides

Lucy van Dijk,Brittany C. Haas,Ngiap-Kie Lim,Kyle Clagg,Jordan J. Dotson,Sean M. Treacy,Katarzyna A. Piechowicz,Vladislav A. Roytman,Haiming Zhang,F. Dean Toste,Scott J. Miller,Francis Gosselin,Matthew S. Sigman

Journal of the American Chemical Society（2023）

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Manufacturing Process for 6-Bromo-n,n-bis(4-methoxybenzyl)-4-methyl-5-(trifluorometh Yl)pyridin-2-amine, a Key Intermediate in the Synthesis of KRAS G12C Inhibitor Divarasib

Jeff Shen,Nicholas A. White,Qingping Tian,Lauren E. Sirois,Haiming Zhang, Francis Gosselin

Organic process research & developmentno. 1 (2023): 92-101

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Practical Synthesis of Reactive Immuno-PET Linker-Chelator (1R,2R)-RESCA-TFP

Nicholas Wong,Eileen Zhao, Jiangyin Bao,Stefan G. Koenig,Carmela Molinaro,Jacob C. Timmerman,Haiming Zhang,C. Gregory Sowell, Francis Gosselin

Organic Process Research &amp Developmentno. 7 (2023): 1400-1405

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Synthesis of a Highly Functionalized Quinazoline Organozinc Toward KRAS G12C Inhibitor Divarasib (GDC-6036), Enabled Through Continuous Flow Chemistry

Sean M. Kelly,Rene Lebl,Thomas C. Malig,Thomas M. Bass, Dominique Kummli,Dainis Kaldre,Ugo Orcel, Lars Trondlin, David Linder,Joerg Sedelmeier,Stephan Bachmann,Chong Han,Haiming Zhang,Francis Gosselin

Organic process research & development (2023)

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Distinguished Scientist

论文共 128 篇作者统计合作学者相似作者