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Why can some people tolerate exposure to DNA damaging agents such as radiation, sunlight, reactive oxygen species and tobacco smoke, while others develop disease? Why do some cancers respond to radiation and chemotherapy, while others do not? Research in the Nagel lab is focused on finding answers to these questions by studying DNA repair. We are using novel multiplex, cell-based DNA repair assays (FM-HCR) together with biochemical and biophysical approaches to understand DNA repair at the molecular, cellular and population levels, with the long-term goal of advancing personalized prevention and treatment of disease.
One area of research is focused on defining the structural and mechanistic biology of the molecular machines that repair DNA damage. This project is aimed at understanding how mutations affect the function of DNA repair complexes, and identifying cancer-specific therapeutic targets.
Why can some people tolerate exposure to DNA damaging agents such as radiation, sunlight, reactive oxygen species and tobacco smoke, while others develop disease? Why do some cancers respond to radiation and chemotherapy, while others do not? Research in the Nagel lab is focused on finding answers to these questions by studying DNA repair. We are using novel multiplex, cell-based DNA repair assays (FM-HCR) together with biochemical and biophysical approaches to understand DNA repair at the molecular, cellular and population levels, with the long-term goal of advancing personalized prevention and treatment of disease.
One area of research is focused on defining the structural and mechanistic biology of the molecular machines that repair DNA damage. This project is aimed at understanding how mutations affect the function of DNA repair complexes, and identifying cancer-specific therapeutic targets.
Research Interests
Papers共 71 篇Author StatisticsCo-AuthorSimilar Experts
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Daniel J Laverty,Shiv K Gupta,Gary A Bradshaw, Alexander S Hunter,Brett L Carlson, Nery Matias Calmo,Jiajia Chen,Shulan Tian,Jann N Sarkaria,Zachary D Nagel
Nature communicationsno. 1 (2024): 5294-5294
Gergely Rona,Bearach Miwatani-Minter,Qingyue Zhang,Hailey V. Goldberg,Marc A. Kerzhnerman, Jesse B. Howard,Daniele Simoneschi, Ethan Lane, John W. Hobbs,Elizabeth Sassani,Andrew A. Wang,Sarah Keegan,Daniel J. Laverty,Cortt G. Piett,Lorinc S. Pongor, Miranda Li Xu,Joshua Andrade,Anish Thomas,Piotr Sicinski,Manor Askenazi,Beatrix Ueberheide,David Fenyö,Zachary D. Nagel,Michele Pagano
Molecular Cell (2024)
The Journal of biological chemistryno. 9 (2024): 107579-107579
International Journal of Molecular Sciencesno. 14 (2024): 7670
Jiajia Chen,Daniel J. Laverty,Surabhi Talele, Ashwin Bale,Brett L. Carlson,Kendra A. Porath,Katrina K. Bakken,Danielle M. Burgenske,Paul A. Decker,Rachael A. Vaubel,Jeanette E. Eckel-Passow, Rohit Bhargava,Zhenkun Lou,Petra Hamerlik,Brendan Harley,William F. Elmquist,Zachary D. Nagel,Shiv K. Gupta,Jann N. Sarkaria
Science Translational Medicineno. 734 (2024)
Genetics Population Genetics - From DNA to Evolutionary Biology (2024)
Aris A Polyzos, Ana Cheong, Jung Hyun Yoo, Lana Blagec, Sneh M Toprani,Zachary D Nagel,Cynthia T McMurray
Nature Communicationsno. 1 (2024): 7726-7726
Needa Brown,Paul Rocchi,Lena Carmes,Romy Guthier,Meghna Iyer,Lea Seban, Toby Morris,Stephanie Bennett,Michael Lavelle,Johany Penailillo,Ruben Carrasco, Chris Williams,Elizabeth Huynh, Zhaohui Han,Evangelia Kaza,Tristan Doussineau,Sneh M. Toprani,Xingping Qin,Zachary D. Nagel,Kristopher A. Sarosiek,Agnes Hagege,Sandrine Dufort,Guillaume Bort,Francois Lux,Olivier Tillement,Ross Berbeco
Theranosticsno. 14 (2023): 4711-4729
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS (2023): 60-61
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Cancer Researchno. 7_Supplement (2023): 6487-6487
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Author Statistics
#Papers: 71
#Citation: 2892
H-Index: 22
G-Index: 42
Sociability: 6
Diversity: 2
Activity: 57
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