Objective: To evaluate whether wedge resection (WR) was appropriate for the patients with peripheral T1 N0 solitary subsolid invasive lung adenocarcinoma. Methods: Patients with peripheral T1N0 solitary subsolid invasive lung adenocarcinoma who received sublobar resection were retrospectively reviewed. Clinicopathologic characteristics, 5-year recurrence-free survival, and 5-year lung cancer-specific overall survival were analyzed. Cox regression model was used to elucidate risk factors for recurrence. Results: Two hundred fifty-eight patients receiving WR and 1245 patients receiving segmentectomy were included. The mean follow-up time was 36.87 +/- 16.21 months. Five-year recurrence-free survival following WR was 96.89% for patients with ground-glass nodule (GGN) <= 2 cm and 0.25< consolidation-to-tumor ratio (CTR) <= 0.5, not statistically different from 100% for those with GGN <= 2 cm and CTR <= 0.25 (P = .231). The 5-year recurrence-free survival was 90.12% for patients with GGN between 2 and 3 cm and CTR <= 0.5, significantly lower than that of patients with GGN <= 2 cm and CTR <= 0.25 (P = .046). For patients with GGN <= 2 cm and 0.25