Dr. Yueming Li studies disease mechanism of Cancer and Alzheimer’s, with the goal of developing novel therapeutics for clinical use.

The main interests of his laboratory are to elucidate the mechanism of γ-secretase-dependent Notch signaling and amyloid precursor protein (APP) processing under physiological and pathological conditions and to develop target-based therapies. His work in g-secretase assays, identification and reconstitution of g-secretase, the regulation of g-secretase and inhibitor development and the mechanism of action of g-secretase modulators has significantly advanced our understanding of the molecular pathogenesis of Alzheimer’s disease and therapeutic development. He is a recipient of the Zenith Fellows Award from the Alzheimer’s Association. He is a recipient of the MetLife Foundation 2013 Awards for Medical Research in Alzheimer’s disease. He was elected as an AAAS Fellow of the American Association for the Advancement of Science.