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A number of age-related pathologies are associated with abnormal telomere length, suggesting that telomere defects may play a role in aging. It is believed that owing to its repetitive sequence, telomere can form unusual secondary structures (e.g., G-quadruplex and a lariat-like T-loop configuration), both of which impact telomere maintenance. We investigate the hypothesis that inadequate DNA structural resolution would impact telomere maintenance and function. Using a combination of molecular, genetic, and biochemical approaches, we are interested in probing (1) the key genes that modulate unique DNA secondary structures at telomeres; and (2) the contributions of DNA resolution deficiency to telomere defects in aging and premature aging syndromes. These studies will enhance our understanding of how DNA resolution deficiencies affect telomere maintenance and thus aging and related human diseases.
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Papers共 61 篇Author StatisticsCo-AuthorSimilar Experts
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Allison B. Herman,Dimitrios Tsitsipatis,Carlos Anerillas,Krystyna Mazan-Mamczarz,Angelica E. Carr,Jordan M. Gregg,Mingyi Wang,Jing Zhang,Marc Michel, Charnae' A. Henry-Smith,Sophia C. Harris,Rachel Munk,Jennifer L. Martindale,Yulan Piao,Jinshui Fan,Julie A. Mattison,Supriyo De,Kotb Abdelmohsen,Robert W. Maul,Toshiko Tanaka,Ann Zenobia Moore,Megan E. DeMouth,Simone Sidoli,Luigi Ferrucci,Yie Liu,Rafael de Cabo,Edward G. Lakatta,Myriam Gorospe
Kotb Abdelmohsen,Allison B Herman,Angelica E Carr, Charnae' A Henry-Smith,Martina Rossi,Qiong Meng,Jen-Hao Yang,Dimitrios Tsitsipatis, Alhassan Bangura,Rachel Munk,Jennifer L Martindale,Carlos J Nogueras-Ortiz,Jon Hao,Yi Gong,Yie Liu,Chang-Yi Cui,Lisa M Hartnell,Nathan L Price,Luigi Ferrucci,Dimitrios Kapogiannis,Rafael de Cabo,Myriam Gorospe
Journal of extracellular biologyno. 8 (2023)
Frontiers in aging (2021): 785171
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#Papers: 61
#Citation: 2378
H-Index: 28
G-Index: 48
Sociability: 6
Diversity: 3
Activity: 47
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