基本信息
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职业迁徙
个人简介
Current Positions:
Professor of Surgery, Microbiology and Immunology, and Pharmacology and Toxicology
Endowed Chair in Translational Research, James Graham Brown Cancer Center
Director, Division of Immunotherapy, UofL School of Medicine
Research Description:
Dr. Yan’s current major research interests are to understand the cellular and molecular mechanisms by which yeast-derived polysaccharide b-glucan modulates immunosuppressive myeloid cells to enhance antitumor immunotherapy using mouse tumor models and human cancer patients. In addition, this laboratory has recently discovered that gdT cells are the major cellular source of inflammatory cytokine IL-17 in psoriatic skin lesions and human colon cancer. This line of research investigates the roles of innate gdT cells in health and diseases. They are interested in gdT17 cell development, metabolism, and signaling pathways that regulate their activation and function. The third major area of interest in Dr. Yan’s laboratory involves the roles of B-cells in the regulation of autoreactive T-cell activation and tolerance using a murine systemic lupus erythematosus (SLE) model as well as human lung cancer. They are interested in B cell repertoire and how T-B cell collaboration in cancer shapes antitumor T-cell response. Knowledge gained from these studies has led them to develop effective vaccines for cancer and autoimmune diseases.
Professor of Surgery, Microbiology and Immunology, and Pharmacology and Toxicology
Endowed Chair in Translational Research, James Graham Brown Cancer Center
Director, Division of Immunotherapy, UofL School of Medicine
Research Description:
Dr. Yan’s current major research interests are to understand the cellular and molecular mechanisms by which yeast-derived polysaccharide b-glucan modulates immunosuppressive myeloid cells to enhance antitumor immunotherapy using mouse tumor models and human cancer patients. In addition, this laboratory has recently discovered that gdT cells are the major cellular source of inflammatory cytokine IL-17 in psoriatic skin lesions and human colon cancer. This line of research investigates the roles of innate gdT cells in health and diseases. They are interested in gdT17 cell development, metabolism, and signaling pathways that regulate their activation and function. The third major area of interest in Dr. Yan’s laboratory involves the roles of B-cells in the regulation of autoreactive T-cell activation and tolerance using a murine systemic lupus erythematosus (SLE) model as well as human lung cancer. They are interested in B cell repertoire and how T-B cell collaboration in cancer shapes antitumor T-cell response. Knowledge gained from these studies has led them to develop effective vaccines for cancer and autoimmune diseases.
研究兴趣
论文共 261 篇作者统计合作学者相似作者
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引用量
主题
期刊级别
合作者
合作机构
Nature communicationsno. 1 (2024)
Bio-protocolno. 1 (2024): e4914-e4914
Yongyuan Chen, Zheyu Shao, Zhixing Hao,Zhongwei Xin,Xiaoke Chen,Lijian Huang,Di Chen,Mingjie Lin, Qinyuan Liu, Xia Xu,Jinfan Li,Dang Wu,Jun Yan,Ying Chai,Pin Wu
JOURNAL FOR IMMUNOTHERAPY OF CANCERno. 8 (2024): 1-20
BIO-PROTOCOLno. 1 (2024)
Small (2024)
Kalpani de Silva,Jun Yan
The Journal of investigative dermatologyno. 10 (2024): 2111-2113
Hong Li,Jun Yan
Cancer Researchno. 6_Supplement (2024): 6533-6533
Chuanlin Ding,Rejeena Shrestha, Xiaojuan Zhu,Anne E. Geller,Shouzhen Wu,Matthew R. Woeste,Wenqian Li,Haomin Wang,Fang Yuan,Raobo Xu,Julia H. Chariker,Xiaoling Hu,Hong Li,David Tieri,Huang-Ge Zhang,Eric C. Rouchka,Robert Mitchell,Leah J. Siskind,Xiang Zhang,Xiaoji G. Xu,Kelly M. McMasters,Yan Yu,Jun Yan
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作者统计
#Papers: 261
#Citation: 12049
H-Index: 57
G-Index: 104
Sociability: 7
Diversity: 0
Activity: 3
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