The main focus of my research is to understand the fundamental role of phospholipids and their oxygenated species in cell death pathways including apoptosis, necroptosis, ferroptosis and mitophagy. My studies discovered that the generation of cardiolipin oxygenated species is essential for the execution of the apoptotic cell death pathway and provide insight into the role of reactive oxygen species in triggering cell death pathways. My significant contribution to a study on the mechanisms responsible for the degradation of injured mitochondria by macroautophagy resulted in the discovery of a new regulatory pathway involved in the quality control of mitochondria realized via elimination of damaged organelles. Particularly, redistribution of cardiolipin from the inner to the outer mitochondrial membrane serves as an “eat-me” signal for the elimination of damaged mitochondria in cells. In addition, my contribution to the investigation of the role of lipid hydroperoxides in ferroptosis revealed a complex lipid oxidation signature associated with the ferroptotic cell death pathway.