Xin Shelley Wang's clinical and translational research focuses on the measurement of patient-reported outcomes (PROs), the impact of culture and nationality on symptom reporting, and mechanism-driven interventions for cancer-related symptoms. She investigates symptom burden in cancer survivors and in patients who are undergoing active treatment or who have advanced disease. Among those undergoing aggressive therapies, such as concurrent chemoradiation, cancer surgery, and stem cell transplant, her research in the area of cancer-related fatigue and other sickness symptoms has illustrated the important relationship between inflammatory cytokines and the development of major symptom burden―a better understanding of which might lead to mechanism-driven symptom control. She has expertise in conducting longitudinal studies and interpreting the clinical meaningfulness of PRO data. These methods are applicable to both clinical practice and clinical trials.