His scientific interests are in the field of genetics of Parkinson's disease and related conditions for which he has received many national and international awards.
Recently he has worked with human-derived samples with known genetic mutations and signatures. He has participated in various induced pluripotent stem (iPS) cells projects since 2009 and has led the Mayo Clinic component of three iPS cells grants sponsored by the National Institute of Neurological Disorders and Stroke and the Mayo Clinic Center for Regenerative Biotherapeutics.
Dr. Wszolek has published extensively in peer-reviewed journals and has spoken at national and international meetings. He holds several patents for discoveries related to the genetics of parkinsonism.